COVID-associated pediatric hospitalization and ICU admission trends across a multi-state health system and the broader US population

Published in medRxiv

April 5, 2021

Abstract: Public health concerns are emerging based on reports of new SARS-CoV-2 variant strains purportedly triggering a rise in COVID-associated hospitalizations and ICU admissions, particularly in younger patients and the pediatric population. However, analyzing health records of COVID patients from the electronic health records (EHRs) of a multi-state US healthcare system, we find that there is actually a significant drop in COVID-associated hospitalization rates and ICU admission rates in March 2021 compared to February 2021. We further triangulate these EHR-derived insights with the official US government epidemiological data sets to show that during this same time period, there is no apparent nation-wide spike in pediatric hospitalizations. Our study motivates the need to develop a real-time system that integrates various COVID hospitalization and ICU monitoring efforts from the EHR databases of various health systems together with national epidemiological data sets. By infusing SARS-CoV-2 genomic sequencing data to flag potentially new or emergent viral strains, as well as county-level COVID vaccine rollout rates and shifts in SARS-CoV-2 PCR positivity rates into such a real-time monitoring system, public health policies and media reporting can be more effectively informed through the rigor of holistic biomedical data sciences. 

 

Authors:

AJ Venkatakrishnan, Colin Pawlowski, John C. O'Horo, Andrew D. BadleyJohn Halamka, Venky Soundararajan

nference, Cambridge, MA 02142
Mayo Clinic, Rochester, MN 55905
 

Correspondence: Venky Soundararajan (venky@nference.net)

Affiliations:

nference-logo-publications-1

mayo-logo-3-3-Mar-05-2021-08-48-39-00-PM

Copyright:

The copyright holder for this preprint is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.