Comparison of two highly-effective mRNA vaccines for COVID-19 during periods of Alpha and Delta variant prevalence

Posted in medRxiv

(Aug 8 2021)

Cited By The White House · Centers for Disease Control and Prevention (CDC)

Featured in Reuters (August 2021) · Reuters (August 2021) · Forbes · Politico · USA Today · NBC News · Washington Post · CNBC · NPR · The Hill · ABC News · Wall Street Journal · FOX News · Inquirer · Endpoint News · The Independent · The Telegraph · MedPage Today (August 2021) · MedPage Today (August 2021) · CBS News · LA Times · India Times Post· SF Chronicle · Star Tribune · Business Insider · BestLife · The Observer · The Daily Express ·  National Geographic (August 2021) · National Geographic (August 2021) · New York Post · CNN Brasil · Correio da Manhã · NJ.com · Kurier · Axios (August 2021) · Axios (August 2021) · Fortune (August 2021) · Fortune (August 2021) · Drugs.com · US News · New York Magazine · The Guardian · Bloomberg · SF Gate · Politifact · Times of Israel · Nasdaq · NBC New York · Becker's Hospital Review · The US Sun · healthline

Television Coverage in BBC World News

Arjun Puranik, Patrick J Lenehan, Eli Silvert, Michiel JM Niesen,...

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Authored by nference  Mayo Clinic

Although clinical trials and real-world studies have affirmed the effectiveness and safety of the FDA-authorized COVID-19 vaccines, reports of breakthrough infections and persistent emergence of new variants highlight the need to vigilantly monitor the effectiveness of these vaccines ...

Correspondence: Venky Soundararajan (venky@nference.net)



Mapping each pre-existing condition’s association to short-term and long-term COVID-19 complications

(Jul 27 2021)

Originally posted in medRxiv

(Dec 4 2020)

AJ Venkatakrishnan, Colin Pawlowski, David Zemmour, Travis Hughes,...

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Authored by nference  Mayo Clinic

Understanding the relationships between pre-existing conditions and complications of COVID-19 infection is critical to identifying which patients will develop severe disease. Here, we leverage 1.1 million clinical notes from 1,903 hospitalized COVID-19 patients and deep neural network models to characterize ...

Correspondence: Venky Soundararajan (venky@nference.net)



COVID-19 vaccines dampen genomic diversity of SARS-CoV-2: Unvaccinated patients exhibit more antigenic mutational variance

Posted in medRxiv

(Jul 5 2021)

Michiel J.M. Niesen, Praveen Anand, Eli Silvert, Rohit Suratekar,...

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Authored by nference  Mayo Clinic

The raging COVID-19 pandemic in India and reports of “vaccine breakthrough infections” globally have raised alarm mandating the characterization of the immunoevasive features of SARS-CoV-2. Here, we systematically analyzed over 1.3 million SARSCoV-2 genomes from 178 countries ...

Correspondence: Venky Soundararajan (venky@nference.net)



FDA-authorized COVID-19 vaccines are effective per real-world evidence synthesized across a multi-state health system

Published in Cell Med

(Jun 28 2021)

Originally Posted in OSF (Feb 17 2021) and medRxiv (Feb 27 2021)

Colin Pawlowski, Patrick Lenehan, Arjun Puranik, Vineet Agarwal, AJ...

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Authored by nference  Mayo Clinic

Large Phase 3 clinical trials of the two FDA-authorized COVID-19 vaccines, mRNA-1273 (Moderna) and BNT162b2 (Pfizer/BioNTech), have demonstrated efficacies of 94.1% (n = 30,420, 95% CI: 89.3-96.8) and 95% (n = 43,448, 95% CI: 90.3-97.6) in preventing symptomatic COVID-19, respectively ...

Correspondence: Venky Soundararajan (venky@nference.net)



Real-time analysis of a mass vaccination effort via an Artificial Intelligence platform confirms the safety of FDA-authorized COVID-19 vaccines

Published in Cell Med

(Jun 28 2021)

Originally Posted in medRxiv

(Feb 27 2021)

Reid McMurry, Patrick J. Lenehan, Samir Awasthi, Eli Silvert, Arjun...

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Authored by nference  Mayo Clinic

As the COVID-19 vaccination campaign unfolds as one of the most rapid and widespread in history, it is important to continuously assess the real world safety of the FDA-authorized vaccines. Curation from large-scale electronic health records (EHRs) allows for near real-time safety evaluations that were not previously possible ...

Correspondence: Venky Soundararajan (venky@nference.net)



Anemia during SARS-CoV-2 infection is associated with rehospitalization after viral clearance

(Jun 24 2021)

Originally Posted in medRxiv

(Jan 19 2021)

Patrick Lenehan, Eshwan Ramudu, AJ Venkatakrishnan, Gabriela Berner, 

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Authored by nference  Mayo Clinic

Patients with COVID-19 can experience symptoms and complications after viral clearance. It is important to identify clinical features of patients who are likely to experience these prolonged effects. We conducted a retrospective study to compare longitudinal laboratory test measurements (hemoglobin, hematocrit ...
Correspondence: Venky Soundararajan (venky@nference.net)


Cerebral Venous Sinus Thrombosis is not Significantly Linked to COVID-19 Vaccines or Non-COVID Vaccines in a Large Multi-State Health System

(Jun 16 2021)

Originally Posted in medRxiv 

(Apr 23 2021)

Colin Pawlowski, John Rincón-Hekking, Samir Awasthi, Viral Pandey, ...

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Authored by nference  Mayo Clinic

 

This real-world evidence-based study finds that CVST is rare and is not significantly associated with COVID-19 vaccination in our patient cohort. Limitations include the rarity of CVST in our dataset, a relatively small number of J&J COVID-19 vaccination events ...

Correspondence: Venky Soundararajan (venky@nference.net) 


 
 

Antigenic minimalism of SARS-CoV-2 is linked to surges in COVID-19 community transmission and vaccine breakthrough infections

Posted in medRxiv

(May 31 2021)

A.J. Venkatakrishnan, Praveen Anand, Patrick Lenehan, Pritha Ghosh,...

more

Authored by nference  Mayo Clinic

The raging COVID-19 pandemic in India and reports of “vaccine breakthrough infections” globally have raised alarm mandating the characterization of the immunoevasive features of SARS-CoV-2. Here, we systematically analyzed over 1.3 million SARSCoV-2 genomes from 178 countries ...

Correspondence: Venky Soundararajan (venky@nference.net), A.J. Venkatakrishnan (aj@nference.net)



Building a best-in-class de-identification tool for electronic medical records through ensemble learning

Published in Cell Patterns

(May 12 2021)

Originally Posted in medRxiv

(Feb 23 2021)

Karthik Murugadoss, Ajit Rajasekharan, Bradley Malin, Vineet...

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Authored by nference  Mayo Clinic  Vanderbilt University Medical Center

The natural language portions of an electronic health record (EHR) communicate critical information about disease and treatment progression. However, the presence of personally identifying information in this data constrains its broad reuse. In the United States, the Health Insurance Portability ...
Correspondence: Venky Soundararajan (venky@nference.net), Sankar Ardhanari (sankar@nference.net)


Real-world effectiveness of Ad26.COV2.S adenoviral vector vaccine for COVID-19

Posted in medRxiv

(Apr 30 2021)

Juan Corchado-Garcia, David Puyraimond-Zemmour, Travis Hughes, Tudor...

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Authored by nference Mayo Clinic

In light of the massive and rapid vaccination campaign against COVID-19, continuous real-world effectiveness and safety assessment of the FDA-authorized vaccines is critical to amplify transparency, build public trust, and ultimately improve ...
 
Correspondence: Venky Soundararajan (venky@nference.net), Tyler Wagner (tyler@nference.net)
 


Pre-existing conditions are associated with COVID-19 patients' hospitalization, despite confirmed clearance of SARS-CoV-2 virus

(Mar 23 2021)

Originally Posted in medRxiv

(Nov 3 2020)

Colin PawlowskiAJ VenkatakrishnanEshwan RamuduChristian Kirkup...

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Authored by nference  Mayo Clinic

The current diagnostic gold-standard for SARS-CoV-2 clearance from infected patients is two consecutive negative PCR test results. However, there are anecdotal reports of hospitalization from protracted COVID ...

 

Correspondence: Venky Soundararajan (venky@nference.net)



Enoxaparin is associated with lower rates of thrombosis, kidney injury, and mortality than unfractionated heparin in hospitalized COVID patients

(Mar 9 2021)

Originally Posted in medRxiv

(Oct 11 2020)

Colin Pawlowski, AJ Venkatakrishnan, Christian Kirkup, Gabriela...

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Authored by nference  Mayo Clinic

Although anticoagulants such as unfractionated heparin and low molecular weight heparin (LMWH, e.g. enoxaparin) are both being used for therapeutic mitigation of COVID associated coagulopathy (CAC), differences in their clinical outcomes remain to be investigated ...
Correspondence: Venky Soundararajan (venky@nference.net)


Healthcare disparities among anticoagulation therapies for severe COVID-19 patients in the multi-site VIRUS registry

(Mar 5 2021)

Originally Posted in medRxiv

(Nov 10 2020)

Christian Kirkup, Colin Pawlowski, Arjun Puranik, Ian Conrad, John...

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Authored by nference  Mayo Clinic  University of Cincinnati Beth Israel Deaconess Medical Center Banner University Medical Center  Kuban State Medical University Cox Medical Center Stamford Health St. Joseph's Candler Health System

COVID-19 patients are at an increased risk of thrombosis and various anticoagulants are being used in patient management without an established standard-of-care. Here, we analyze hospitalized and ICU patient outcomes from the Viral Infection and Respiratory illness Universal Study (VIRUS) registry ...

Correspondence: AJ Venkatakrishnan (aj@nference.net), Venky Soundararajan (venky@nference.net) 



Exploratory analysis of immunization records highlights decreased SARS-CoV-2 rates in individuals with recent non-COVID-19 vaccinations

(Feb 26 2021)

Originally Posted in medRxiv

(Jul 29 2020)

Colin Pawlowski, Arjun Puranik, Hari Bandi, AJ Venkatakrishnan,...

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Authored by nference  Mayo Clinic

Multiple clinical studies are ongoing to assess whether existing vaccines may afford protection against SARS-CoV-2 infection through trained immunity. In this exploratory study, we analyze immunization ...

Correspondence: Venky Soundararajan (venky@nference.net)



Augmented curation of clinical notes from a massive EHR system reveals symptoms of impending COVID-19 diagnosis

Published in eLife

(Jul 7 2020)

Originally Posted in medRxiv

(Jun 11 2020)

Tyler Wagner, FNU Shweta, Karthik Murugadoss, Samir Awasthi, AJ...

more

Authored by nference Mayo Clinic

The COVID-19 pandemic demands assimilation of all biomedical knowledge to decode mechanisms of pathogenesis. Despite the recent renaissance in neural networks, a platform for the real-time synthesis of the exponentially growing biomedical literature and deep omics insights is unavailable ...

Correspondence: Andrew Badley (badley.andrew@mayo.edu), Venky Soundararajan (venky@nference.net) 


 
 
 

SARS-CoV-2 strategically mimics proteolytic activation of human ENaC

Published in eLife

(May 26 2020)

Originally Posted in bioRxiv

(Apr 30 2020)

Featured in The Scientist

Praveen Anand, Arjun Puranik, Murali Aravamudan, AJ Venkatakrishnan,...

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Authored by nference

Molecular mimicry of host proteins is an evolutionary strategy adopted by viruses to evade immune surveillance and exploit host cell systems. We report that SARS-CoV-2 has evolved a unique S1/S2 cleavage site (RRARSVAS), absent in any previous coronavirus sequenced, that results in mimicry ...
Correspondence: AJ Venkatakrishnan (aj@nference.net), Venky Soundararajan (venky@nference.net)

 
 
 

Knowledge synthesis of 100 million biomedical documents augments the deep expression profiling of coronavirus receptors

Published in eLife

(May 28 2020)

Originally Posted in bioRxiv

(Mar 29 2020)

Featured in S T A T

AJ Venkatakrishnan, Arjun Puranik, Akash Anand, David Zemmour, Xiang...

more

Authored by nference Janssen

The COVID-19 pandemic demands assimilation of all biomedical knowledge to decode mechanisms of pathogenesis. Despite the recent renaissance in neural networks, a platform for the real-time synthesis of the exponentially growing biomedical literature and deep omics insights is unavailable ...

Correspondence: Venky Soundararajan (venky@nference.net) 


 
 
 

Publications
















Published in eLife

(May 26 2020)

Originally Posted in bioRxiv

(Apr 30 2020)

Featured in The Scientist