Durability analysis of the highly effective BNT162b2 vaccine against COVID-19

Posted in medRxiv

(Sep 7 2021)

Featured in Nature · Star Tribune · Yahoo News

 

Arjun Puranik, Patrick Lenehan, John C O'Horo, Michiel JM Niesen,...

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Authored by nference  Mayo Clinic

SARS-CoV-2 breakthrough infections have been increasingly reported in fully vaccinated individuals. We conducted a test-negative case-control study to assess the durability of protection after full vaccination with BNT162b2, defined as ...

Correspondence: Venky Soundararajan (venky@nference.net) and Andrew Badley (badley.andrew@mayo.edu



High diversity in Delta variant across countries revealed via genome-wide analysis of SARS-CoV-2 beyond the Spike protein

Posted in bioRxiv

(Sep 2 2021)

Pritha Ghosh, Rohit Suratekar, Michiel J.M. Niesen, Praveen Anand,...

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Authored by nference

The highly contagious Delta variant of SARS-CoV-2 has emerged as the new dominant global strain, and reports of reduced effectiveness of COVID-19 vaccines against the Delta variant are highly concerning. While there has been extensive focus on understanding the amino acid mutations in the Delta variant’s Spike protein ...

Correspondence: AJ Venkatakrishnan (aj@nference.net) and Venky Soundararajan (venky@nference.net)



Comparison of two highly-effective mRNA vaccines for COVID-19 during periods of Alpha and Delta variant prevalence

Posted in medRxiv

(Aug 8 2021)

Cited By The White House · Centers for Disease Control and Prevention (CDC) · UK Parliament

Featured in New York Times · Reuters (August 2021) · Reuters (August 2021) · Forbes · Politico · USA Today · NBC News · Washington Post · CNBC · NPR · The Hill · ABC News · Wall Street Journal · FOX News · Inquirer · Endpoint News · The Independent · The Telegraph · MedPage Today (August 2021) · MedPage Today (August 2021) · CBS News · LA Times · India Times Post· SF Chronicle · Star Tribune · Business Insider · BestLife · The Observer · The Daily Express ·  National Geographic (August 2021) · National Geographic (August 2021) · New York Post · CNN Brasil · Correio da Manhã · NJ.com · Kurier · Axios (August 2021) · Axios (August 2021) · Fortune (August 2021) · Fortune (August 2021) · Drugs.com · US News · New York Magazine · The Guardian · Bloomberg · SF Gate · Politifact · Times of Israel · Nasdaq · NBC New York · Becker's Hospital Review · The US Sun · healthline

Television Coverage in BBC World News

Arjun Puranik, Patrick J Lenehan, Eli Silvert, Michiel JM Niesen,...

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Authored by nference  Mayo Clinic

Although clinical trials and real-world studies have affirmed the effectiveness and safety of the FDA-authorized COVID-19 vaccines, reports of breakthrough infections and persistent emergence of new variants highlight the need to vigilantly monitor the effectiveness of these vaccines ...

Correspondence: Venky Soundararajan (venky@nference.net)



Diversity of Coronavirus Receptors

Posted in Preprints.org

(Aug 2 2021)

Pritha Ghosh, Savita Jayaram, Dhruti Patwardhan, Saranya Marimuthu,...

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Authored by nference

Despite this seeming diversity of host receptors, there may be some common underlying mechanisms that influence the host range, virus transmissibility, and pathogenicity. Understanding these mechanisms may be crucial in not only controlling the ongoing pandemic but also ...

Correspondence: Praveen Anand (praveen@nference.net), Venky Soundararajan (venky@nference.net)



COVID-19 vaccines dampen genomic diversity of SARS-CoV-2: Unvaccinated patients exhibit more antigenic mutational variance

Posted in medRxiv

(Jul 5 2021)

Michiel J.M. Niesen, Praveen Anand, Eli Silvert, Rohit Suratekar,...

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Authored by nference  Mayo Clinic

The raging COVID-19 pandemic in India and reports of “vaccine breakthrough infections” globally have raised alarm mandating the characterization of the immunoevasive features of SARS-CoV-2. Here, we systematically analyzed over 1.3 million SARSCoV-2 genomes from 178 countries ...

Correspondence: Venky Soundararajan (venky@nference.net)



Antigenic minimalism of SARS-CoV-2 is linked to surges in COVID-19 community transmission and vaccine breakthrough infections

Posted in medRxiv

(Jun 14 2021)

A.J. Venkatakrishnan, Praveen Anand, Patrick Lenehan, Pritha Ghosh,...

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Authored by nference  Mayo Clinic

The raging COVID-19 pandemic in India and reports of “vaccine breakthrough infections” globally have raised alarm mandating the characterization of the immunoevasive features of SARS-CoV-2. Here, we systematically analyzed over 1.3 million SARSCoV-2 genomes from 178 countries ...

Correspondence: Venky Soundararajan (venky@nference.net), A.J. Venkatakrishnan (aj@nference.net)



Association of Intravenous Bamlanivimab Use with Reduced Hospitalization, Intensive Care Unit Admission, and Mortality in Patients with Milad to Moderate COVID-19

Posted in medRxiv

(May 25 2021)

Ravindra Ganesh, Colin Pawlowski, John C. O’Horo, Lori L. Arndt,...

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Authored by nference Mayo Clinic

Among high-risk patients with mild to moderate COVID-19, treatment with bamlanivimab was associated with a statistically significant lower rate of hospitalization compared with usual care …

Correspondence: Ravindra Ganesh (ganesh.ravindra@mayo.edu)



Real-world effectiveness of Ad26.COV2.S adenoviral vector vaccine for COVID-19

Posted in medRxiv

(Apr 30 2021)

Juan Corchado-Garcia, David Puyraimond-Zemmour, Travis Hughes, Tudor...

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Authored by nference Mayo Clinic

In light of the massive and rapid vaccination campaign against COVID-19, continuous real-world effectiveness and safety assessment of the FDA-authorized vaccines is critical to amplify transparency, build public trust, and ultimately improve ...
 
Correspondence: Venky Soundararajan (venky@nference.net), Tyler Wagner (tyler@nference.net)
 


Effects of tumor mutation burden on the antigen presentation pathway

Posted in bioRxiv

(Apr 14 2021)

Enrique M. Garcia-Rivera, Jiho Park, Aakash Desai, Romain Boidot,...

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Authored by nference  Mayo Clinic  Georges-Francois LeClerc Cancer Center  Genetic and Immunology Medical Institute  University of Burgundy Franche-Comte

We hypothesized that inactivation of antigen presenting genes (APGs) that result from increased TMBs would result in inherent resistance to immune checkpoint inhibitors. We observed that somatic mutations in APGs were associated with increasing TMBs across 9,418 tumor ...

Correspondence: Aaron Mansfield (mansfield.aaron@mayo.edu)



Hair loss in females and thromboembolism in males are significantly enriched in post-acute sequelae of COVID (PASC) relative to recent medical history

Posted in medRxiv

(Apr 13 2021)

Elliot Akama-Garren, Praveen Anand, Tudor Cristea-Platon, Patrick...

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Authored by nference  Mayo Clinic

The post-acute sequelae of COVID-19 (PASC), also referred to as the ‘long COVID’ syndrome, remains mostly uncharacterized. We leveraged machine-augmented curation of the physician notes to retrospectively contrast the occurrence of symptoms and diseases in COVID-19 patients in the post ...

Correspondence:  Samir Awasthi (samir@nference.net), Venky Soundararajan (venky@nference.net)




Case fatality rates for COVID-19 are higher than case fatality rates for motor vehicle accidents for individuals over 40 years of age

Posted in medRxiv

(Apr 13 2021)

Arjun Puranik, Michiel J.M. Niesen, Emily Lindemer, Patrick Lenehan,...

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Authored by nference

Is a person more likely to die if they get a COVID diagnosis or if they get into a motor vehicle accident? We find that COVID carries the higher case fatality risk for individuals in their 40s and up. In particular, the COVID case fatality risk 1.5-fold more than for motor vehicle accidents for age group 40-49 ...

Correspondence: Colin Pawlowski (colin@nference.net), Venky Soundararajan (venky@nference.net)



Female-male differences in COVID vaccine adverse events have precedence in seasonal flu shots: a potential link to sex-associated baseline gene expression patterns

Posted in medRxiv

(Apr 7 2021)

AJ Venkatakrishnan, Praveen Kumar-M, Eli Silvert, Enrique...

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Authored by nference  Mayo Clinic

Do men and women experience the same adverse events after getting COVID-19 vaccines? Analysis of over 30,000 vaccinated patients shows Increased reporting of nausea and fever among females and males, respectively. This is also observed for prior influenza vaccines, establishing that these ...

 

Correspondence: Venky Soundararajan (venky@nference.net)



COVID-associated pediatric hospitalization and ICU admission trends across a multi-state health system and the broader US population

Posted in medRxiv

(Apr 5 2021)

AJ Venkatakrishnan, Colin Pawlowski, John C. O'Horo, Andrew D....

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Authored by nference  Mayo Clinic

Public health concerns are emerging based on reports of new SARS-CoV-2 variant strains purportedly triggering a rise in COVID-associated hospitalizations and ICU admissions, particularly in younger patients and the pediatric population. However, analyzing health records of COVID ...

Correspondence: Venky Soundararajan (venky@nference.net)



Inference from longitudinal laboratory tests characterizes temporal evolution of COVID-19-associated coagulopathy (CAC)

Published in eLife

(Aug 17 2020)

Featured in Medical Xpress

Colin Pawlowski, Tyler Wagner, Arjun Puranik, Karthik Murugadoss, ...

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Authored by nference  Mayo Clinic  Janssen

Temporal inference from laboratory testing results and triangulation with clinical outcomes extracted from unstructured electronic health record (EHR) provider notes is integral to advancing precision medicine. Here, we studied 246 SARS-CoV-2 PCR-positive (COVIDpos) patients and propensity-matched ...

Correspondence: Venky Soundararajan (venky@nference.net)


 
 

Real-time biomedical knowledge synthesis of the exponentially growing world wide web using unsupervised neural networks

Posted in bioRxiv

(Apr 4 2020)

Tyler Wagner, Samir Awasthi, Gayle Wittenberg, AJ Venkatakrishnan,...

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Authored by nference  Mayo Clinic  Janssen

Decoding disease mechanisms for addressing unmet clinical need demands the rapid assimilation of the exponentially growing biomedical knowledge. These are either inherently unstructured and non-conducive to current computing paradigms or siloed into structured databases requiring ...

Correspondence:  Venky Soundararajan (venky@nference.net)



Recapitulation and retrospective prediction of biomedical associations using temporally-enabled word embeddings

Posted in bioRxiv

(May 7 2019)

Jiho Park, Agustin Lopez-Marquez, Arjun Puranik, Ajit Rajasekharan, ...

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Authored by nference

Malignant pleural mesothelioma is a disease primarily associated with exposure to the carcinogen asbestos. Whereas other carcinogen-related tumors are associated with a high tumor mutation burden, mesothelioma is not. We observed that inter- or intrachromosomal rearrangements ...
Correspondence: Enrique Garcia-Rivera (enrique@nference.net)


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