Real-world effectiveness of Ad26.COV2.S adenoviral vector vaccine for COVID-19

Published in medRxiv

(April 30, 2021)

Juan Corchado-Garcia, David Puyraimond-Zemmour, Travis Hughes ,...

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Authored by nference Mayo Clinic

In light of the massive and rapid vaccination campaign against COVID-19, continuous real-world effectiveness and safety assessment of the FDA-authorized vaccines is critical to amplify transparency, build public trust, and ultimately improve ...
Correspondence: Venky Soundararajan (venky@nference.net),  Tyler Wagner (tyler@nference.net)
 

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Cerebral venous sinus thrombosis (CVST) is not significantly linked to COVID-19 vaccines or non-COVID vaccines in a large multi-state US health system

Posted in medRxivOSF Preprints

(April 23, 2021)

Colin Pawlowski, John Rincón-Hekking, Samir Awasthi, Viral Pandey,...

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Authored by nference Mayo Clinic

In light of the massive and rapid vaccination campaign against COVID-19, continuous real-world effectiveness and safety assessment of the FDA-authorized vaccines is critical to amplify transparency, build public trust, and ultimately improve overall health outcomes. In this study ...

Correspondence: Venky Soundararajan (venky@nference.net)


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Effects of tumor mutation burden on the antigen presentation pathway

Published in bioRxiv

(April 14, 2021)

Enrique M. Garcia-Rivera, Jiho Park, Aakash Desai, Romain Boidot,...

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Authored by nference  Mayo Clinic  Georges-Francois LeClerc Cancer Center  Genetic and Immunology Medical Institute  University of Burgundy Franche-Comte

We hypothesized that inactivation of antigen presenting genes (APGs) that result from increased TMBs would result in inherent resistance to immune checkpoint inhibitors. We observed that somatic mutations in APGs were associated with increasing TMBs across 9,418 tumor ...

Correspondence: Aaron Mansfield (mansfield.aaron@mayo.edu)



Hair loss in females and thromboembolism in males are significantly enriched in post-acute sequelae of COVID (PASC) relative to recent medical history

Published in medRxiv

(April 13 , 2021)

Elliot Akama-Garren, Praveen Anand, Tudor Cristea-Platon, Patrick...

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Authored by nference  Mayo Clinic

The post-acute sequelae of COVID-19 (PASC), also referred to as the ‘long COVID’ syndrome, remains mostly uncharacterized. We leveraged machine-augmented curation of the physician notes to retrospectively contrast the occurrence of symptoms and diseases in COVID-19 patients in the post ...

Correspondence:  Samir Awasthi (samir@nference.net), Venky Soundararajan (venky@nference.net)




Case fatality rates for COVID-19 are higher than case fatality rates for motor vehicle accidents for individuals over 40 years of age

Published in medRxiv

(April 13, 2021)

Arjun Puranik, Michiel J.M. Niesen, Emily Lindemer, Patrick Lenehan,

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Authored by nference

Is a person more likely to die if they get a COVID diagnosis or if they get into a motor vehicle accident? We find that COVID carries the higher case fatality risk for individuals in their 40s and up. In particular, the COVID case fatality risk 1.5-fold more than for motor vehicle accidents for age group 40-49 ...

Correspondence: Colin Pawlowski (colin@nference.net), Venky Soundararajan (venky@nference.net)


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Female-male differences in COVID vaccine adverse events have precedence in seasonal flu shots: a potential link to sex-associated baseline gene expression patterns

Published in medRxiv

(April 7, 2021)

AJ Venkatakrishnan, Praveen Kumar-M, Eli Silvert, Enrique...

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Authored by nference  Mayo Clinic

Do men and women experience the same adverse events after getting COVID-19 vaccines? Analysis of over 30,000 vaccinated patients shows Increased reporting of nausea and fever among females and males, respectively. This is also observed for prior influenza vaccines, establishing that these ...

Correspondence: Venky Soundararajan (venky@nference.net)



COVID-associated pediatric hospitalization and ICU admission trends across a multi-state health system and the broader US population

Published in medRxiv

(April 5, 2021)

AJ Venkatakrishnan, Colin Pawlowski, John C. O'Horo, Andrew D. Badley

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Authored by nference  Mayo Clinic

Public health concerns are emerging based on reports of new SARS-CoV-2 variant strains purportedly triggering a rise in COVID-associated hospitalizations and ICU admissions, particularly in younger patients and the pediatric population. However, analyzing health records of COVID.....

Correspondence: Venky Soundararajan (venky@nference.net)



A literature-derived knowledge graph augments the interpretation of single cell RNA-seq datasets

Published in bioRxiv

(April 4, 2021)

Deeksha Doddahonnaiah, Patrick Lenehan, Travis Hughes, David Zemmour...

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Authored by nference

Single cell RNA-sequencing has enabled the profiling of cellular heterogeneity across diverse tissues and pathologies at unprecedented levels. However, the plethora of knowledge contained within biomedical literature has not yet been leveraged systematically to aid in the annotation and interpretation ...

Correspondence: Venky Soundararajan (venky@nference.net)



Counties with lower insurance coverage are associated with both slower vaccine rollout and higher COVID-19 incidence across the United States

Published in medRxiv

(March 26, 2021 )

Emily Lindemer, Mayank Choudhary, Gregory Donadio, Colin Pawlowski,...

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Authored by nference

We set out to determine the interplay of racial and socioeconomic factors on vaccine coverage and new COVID-19 cases across the US. Our findings demonstrated that the factor most strongly associated with both poor vaccine coverage and high incidence rates was the percent of a county’s ...

Correspondence: Colin Pawlowski (colin@nference.net), Venky Soundararajan (venky@nference.net)


 

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FDA-authorized COVID-19 vaccines are effective per real-world evidence synthesized across a multi-state health system

Published in medRxiv

(Feb. 27, 2021)

Originally Posted in OSF Preprints

(Feb. 17, 2021)

Colin Pawlowski, Patrick Lenehan, Arjun Puranik, Vineet Agarwal, AJ...

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Authored by nference  Mayo Clinic

Large Phase 3 clinical trials of the two FDA-authorized COVID-19 vaccines, mRNA-1273 (Moderna) and BNT162b2 (Pfizer/BioNTech), have demonstrated efficacies of 94.1% (n = 30,420, 95% CI: 89.3-96.8) and 95% (n = 43,448, 95% CI: 90.3-97.6) in preventing symptomatic COVID-19, respectively ...

Correspondence:  Venky Soundararajan (venky@nference.net)

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Real-time analysis of a mass vaccination effort via an Artificial Intelligence platform confirms the safety of FDA-authorized COVID-19 vaccines

Published in medRxiv

(Feb 27, 2021)

Reid McMurry, Patrick J Lenehan, Samir Awasthi, Eli Silvert, Arjun...

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Authored by nference  Mayo Clinic

As the COVID-19 vaccination campaign unfolds as one of the most rapid and widespread in history, it is important to continuously assess the real world safety of the FDA-authorized vaccines. Curation from large-scale electronic health records (EHRs) allows for near real-time safety evaluations that were not previously possible ...

Correspondence: Venky Soundararajan (venky@nference.net)


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Anemia prior to or during COVID-19 is a risk factor for rehospitalization after SARS-CoV-2 clearance

Published in medRxiv

(Jan. 19, 2021)

Patrick Lenehan, Eshwan Ramudu, AJ Venkatakrishnan, Gabriela Berner, 

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Authored by nference  Mayo Clinic

As the number of new and recovering cases continues to rise, it is increasingly important to understand the long-term impacts of COVID-19 beyond the time of active SARS-CoV-2 infection. However, the clinical and molecular biomarkers characterizing patients who are likely to experience longer lasting effects ...
Correspondence: Venky Soundararajan (venky@nference.net)
 


Building a Best-in-Class De-identification Tool for Electronic Medical Records Through Ensemble Learning

Published in medRxiv

(Dec. 23, 2020)

Karthik Murugadoss, Ajit Rajasekharan, Bradley Malin, Vineet...

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Authored by nference  Mayo Clinic  Vanderbilt University Medical Center

The natural language portions of an electronic health record (EHR) communicate critical information about disease and treatment progression. However, the presence of personally identifying information in this data constrains its broad reuse. In the United States, the Health Insurance Portability ...
Correspondence: Venky Soundararajan (venky@nference.net), Sankar Ardhanari (sankar@nference.net)
 

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Mapping each pre-existing condition’s association to short-term and long-term COVID-19 complications

Published in medRxiv

(Dec. 04, 2020)

AJ VenkatakrishnanColin PawlowskiDavid ZemmourTravis Hughes...

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Authored by nference  Mayo Clinic

Understanding the relationships between pre-existing conditions and complications of COVID-19 infection is critical to identifying which patients will develop severe disease. Here, we leverage 1.1 million clinical notes from 1,903 hospitalized COVID-19 patients and deep neural network models to characterize ...
Correspondence: Venky Soundararajan (venky@nference.net)
 


Real-time biomedical knowledge synthesis of the exponentially growing world wide web using unsupervised neural networks

Published in bioRxiv

(April 4, 2020)

Tyler Wagner, Samir Awasthi, Gayle Wittenberg, AJ Venkatakrishnan...

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Authored by nference  Mayo Clinic  Janssen

Decoding disease mechanisms for addressing unmet clinical need demands the rapid assimilation of the exponentially growing biomedical knowledge. These are either inherently unstructured and non-conducive to current computing paradigms or siloed into structured databases requiring ...

Correspondence:  Venky Soundararajan (venky@nference.net)



Recapitulation and Retrospective Prediction of Biomedical Associations Using Temporally-enabled Word Embeddings

Published in bioRxiv

(May 7, 2019)

Jiho Park, Agustin Lopez-Marquez, Arjun Puranik, Ajit Rajasekharan, ...

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Authored by nference

Malignant pleural mesothelioma is a disease primarily associated with exposure to the carcinogen asbestos. Whereas other carcinogen-related tumors are associated with a high tumor mutation burden, mesothelioma is not. We observed that inter- or intrachromosomal rearrangements ...
Correspondence: Enrique Garcia-Rivera (enrique@nference.net)


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